Koichi Watashi Selected Research

sodium-bile acid cotransporter

11/2021	NTCP Oligomerization Occurs Downstream of the NTCP-EGFR Interaction during Hepatitis B Virus Internalization.
12/2020	Establishment of a novel hepatitis B virus culture system using immortalized human hepatocytes.
12/2020	Identification of Two Critical Neutralizing Epitopes in the Receptor Binding Domain of Hepatitis B Virus preS1.
3/2020	Anti-viral effects of interferon-λ3 on hepatitis B virus infection in cell culture.
2/2019	Concept of Viral Inhibitors via NTCP.
1/2019	A Single Adaptive Mutation in Sodium Taurocholate Cotransporting Polypeptide Induced by Hepadnaviruses Determines Virus Species Specificity.
1/2018	Inhibitory effect of fasiglifam on hepatitis B virus infections through suppression of the sodium taurocholate cotransporting polypeptide.
1/2017	Human induced-pluripotent stem cell-derived hepatocyte-like cells as an in vitro model of human hepatitis B virus infection.
1/2016	Human induced pluripotent stem cell-derived hepatic cell lines as a new model for host interaction with hepatitis B virus.
12/2015	A Novel Tricyclic Polyketide, Vanitaracin A, Specifically Inhibits the Entry of Hepatitis B and D Viruses by Targeting Sodium Taurocholate Cotransporting Polypeptide.

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Koichi Watashi Research Topics

Disease

69	Infections 01/2022 - 11/2003
14	Hepatitis B 02/2022 - 11/2013
11	Virus Diseases (Viral Diseases) 01/2022 - 01/2007
10	COVID-19 07/2022 - 01/2021
7	Neoplasms (Cancer) 01/2022 - 08/2010
5	Chronic Hepatitis B 12/2021 - 09/2015
2	Liver Diseases (Liver Disease) 12/2021 - 11/2003
2	Carcinogenesis 01/2021 - 08/2010
2	Communicable Diseases (Infectious Diseases) 01/2021 - 01/2019
2	T-Cell Leukemia (Leukemia, T Cell) 03/2019 - 04/2009
2	Hepatitis 01/2019 - 01/2013
2	Inflammation (Inflammations) 10/2018 - 04/2005
2	Hepatocellular Carcinoma (Hepatoma) 01/2018 - 11/2015
1	Asthma (Bronchial Asthma) 07/2022
1	Merkel Cell Carcinoma 01/2022
1	Gastroenteritis 12/2021
1	Caliciviridae Infections 12/2021
1	Diarrhea 04/2021
1	Pneumonia (Pneumonitis) 04/2021
1	HIV Infections (HIV Infection) 04/2021
1	Hypersensitivity (Allergy) 04/2021
1	Fibrosis (Cirrhosis) 03/2021
1	Hypoxia (Hypoxemia) 01/2021
1	Neoplasm Metastasis (Metastasis) 10/2020
1	Nasopharyngeal Neoplasms (Cancer of the Nasopharynx) 10/2020
1	Chemical and Drug Induced Liver Injury 12/2019

Drug/Important Bio-Agent (IBA)

25	Antiviral Agents (Antivirals)IBA 01/2022 - 01/2007
15	sodium-bile acid cotransporterIBA 11/2021 - 02/2014
8	Pharmaceutical PreparationsIBA 12/2021 - 02/2010
8	Proteins (Proteins, Gene)FDA Link 03/2020 - 11/2003
7	Circular DNAIBA 12/2021 - 09/2014
7	InterferonsIBA 10/2021 - 11/2003
6	Peptides (Polypeptides)IBA 01/2019 - 11/2015
5	Membrane Proteins (Integral Membrane Proteins)IBA 01/2021 - 01/2014
4	VaccinesIBA 01/2022 - 11/2015
4	RNA (Ribonucleic Acid)IBA 12/2021 - 01/2015
4	NucleosidesIBA 01/2020 - 02/2015
4	Cyclosporine (Ciclosporin)FDA LinkGeneric 01/2014 - 01/2007
3	Drug CombinationsIBA 01/2021 - 01/2017
3	DNA (Deoxyribonucleic Acid)IBA 01/2019 - 05/2015
3	LipidsIBA 12/2018 - 11/2010
3	Cyclophilins (Cyclophilin)IBA 08/2014 - 01/2007
2	Neutralizing AntibodiesIBA 01/2022 - 01/2014
2	Polysaccharides (Glycans)IBA 01/2022 - 03/2019
2	Small Interfering RNA (siRNA)IBA 12/2021 - 05/2015
2	CytokinesIBA 12/2021 - 11/2013
2	Troglitazone (Rezulin)FDA Link 11/2021 - 01/2018
2	2,4-thiazolidinedione (thiazolidinedione)IBA 11/2021 - 01/2018
2	Oxygen (Dioxygen)IBA 04/2021 - 01/2021
2	CholesterolIBA 03/2021 - 01/2014
2	OxysterolsIBA 03/2021 - 01/2014
2	Viral ProteinsIBA 01/2021 - 01/2019
2	G-Protein-Coupled Receptors (Receptors, G Protein Coupled)IBA 01/2021 - 01/2018
2	Monoclonal AntibodiesIBA 12/2020 - 02/2016
2	Messenger RNA (mRNA)IBA 01/2019 - 10/2018
2	MicroRNAs (MicroRNA)IBA 07/2018 - 08/2010
2	Clathrin Heavy ChainsIBA 05/2015 - 12/2014
2	NF-kappa B (NF-kB)IBA 04/2009 - 04/2005
1	ciclesonide FDA Link 07/2022
1	niranthinIBA 02/2022
1	CyclopropanesIBA 02/2022
1	LignansIBA 02/2022
1	Sialic AcidsIBA 01/2022
1	N-(2-cyanoethylene)urea (BA 1)IBA 01/2022
1	N-methyl-valyl-amiclenomycin (BA 2)IBA 01/2022
1	N-Acetylneuraminic Acid (Sialic Acid)IBA 01/2022
1	Nonsense Codon (Nonsense Mutation)IBA 01/2022
1	exophillic acidIBA 01/2022
1	Angiotensin-Converting Enzyme 2IBA 01/2022
1	Tumor Viral Antigens (Large T Antigen)IBA 01/2022
1	Viral DNAIBA 01/2022
1	1,2- di- (4- sulfamidophenyl)- 4- butylpyrazolidine- 3,5- dione (DSB)IBA 12/2021
1	dasabuvirIBA 12/2021
1	Basic-Leucine Zipper Transcription FactorsIBA 12/2021
1	pgRNAIBA 12/2021
1	LuciferasesIBA 12/2021
1	Virus ReceptorsIBA 11/2021
1	Rifampin (Rifampicin)FDA LinkGeneric 04/2021
1	Blood Glucose (Blood Sugar)IBA 04/2021
1	AntigensIBA 04/2021
1	Investigational DrugsIBA 04/2021
1	Nelfinavir (Viracept)FDA Link 04/2021
1	CreatinineIBA 04/2021
1	remdesivirIBA 01/2021
1	roxadustatIBA 01/2021
1	6alpha-ethyl-23(S)-methylcholic acidIBA 01/2021
1	Prolyl-Hydroxylase InhibitorsIBA 01/2021
1	Hydroxychloroquine (Plaquenil)FDA LinkGeneric 01/2021
1	Biological ProductsIBA 01/2021
1	Glucose (Dextrose)FDA LinkGeneric 01/2021
1	Hepatitis B Surface Antigens (HBsAg)FDA Link 01/2021
1	EpitopesIBA 12/2020
1	Mitochondrial DNA (mtDNA)IBA 10/2020
1	Mitogen-Activated Protein KinasesIBA 01/2020
1	Phosphates (Orthophosphate)IBA 01/2020
1	Phosphatidylinositols (Phosphatidylinositol)IBA 01/2020
1	NucleotidesIBA 10/2019

Therapy/Procedure

8	Therapeutics 07/2022 - 09/2015
1	Contraception (Birth Control) 04/2021
1	Immunotherapy 03/2020